49ers Suffer Another Injury On First Drive Of Preseason Opener

The last thing the San Francisco 49ers needed was another injury.

Already without almost two dozen players, plus coach Kyle Shanahan shaking off a concussion, the Niners couldn’t make it one drive in their first preseason game without losing another player.

Cornerback Jack Jones, one of the few potential impact players who suited up for the 49ers, left during the Titans’ opening drive with a hand injury and was ruled out for the remainder of the game.

Jones, a fifth-year veteran, signed with San Francisco as free agent and had been a camp standout as a second-teamer in what has been the 49ers’ strongest unit so far.

The secondary had also been the 49ers’ healthiest group with only safety Malik Mustapha (hamstring) counting among the 17 players currently managing injuries. That should help if Jones is forced to miss time.

He was replaced by fourth-round rookie Ephesians Prysock. First-stringers Deommodore Lenoir and Renardo Green sat out like the majority of San Francisco’s projected starters.

The 49ers did not specify the nature or the severity of Jones’ injury.

He left the game after helping run down Titans running back Tyjae Spears on a 25-yard gain on the eighth play from scrimmage of the game.

Tennessee’s starters finished off the 95-yard scoring drive against the 49ers’ backups.

The 49ers’ reserve offense answered with a touchdown drive, and third-string quarterback Kurtis Rourke completed 12 of 14 passes for 100 yards, but he later left, too, with a rib injury.

Rourke was later ruled out, as well, leaving Adrian Martinez as the only quarterback in uniform.

Rourke, a seventh-round pick in 2025, missed all of last season recovering from ACL surgery.

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49ers injuries

• RB Kaelon Black (adductor)

• DE Nick Bosa (tendinitis)

• WR Jacob Cowing (hip flexor)

• WR Mike Evans (quad)

• LB Luke Gifford (hamstring)

• RB Isaac Guerendo (pec)

• RB Jordan James (ribs)

• FB Kyle Juszczyk (finger)

• OT Vederian Lowe (ankle)

• WR Christian Kirk (calf)

• TE George Kittle (Achilles)

• RB Christian McCaffrey (tightness)

• S Malik Mustapha (hamstring)

• OL Brett Toth (concussion)

• DL Keion White (quad)

• DE Mykel Williams (knee)

• OL Nick Zakelj (elbow)