Dolphins Vs. Colts Odds: Opening Lines For Week 10 Matchup

The Miami Dolphins face off against the Indianapolis Colts in Week 10, a game featuring two teams vying for the first-overall pick in the 2027 NFL Draft. Well, technically. The Colts, 2-7, could claim the top spot, but they do not own their own first-round for the next draft, with the New York Jets holding that selection as part of an in-season trade last year that sent cornerback Sauce Gardner to Indianapolis.

Despite the Dolphins’ positive signs of growth over the past several weeks, the oddsmakers have given the Colts a slight nod in this game. The FanDuel Sportsbook line opened with Indianapolis favored by 2.5 points, slightly under the typical three-point advantage given to a home team, and it has remained steady as of Tuesday morning.

The point total is set at 40.5, while Miami is +116 on the money line for the straight-up win. The Colts are -136 for the win.

This week could see massive changes in odds as Tuesday’s trade deadline approaches. Indianapolis is expected to be sellers today, with running back Jonathan Taylor considered one of the top available players on the market, and rumors swirling around defensive tackle Grover Stewart and quarterback Daniel Jones. If the Colts do start making trades ahead of the 4 p.m. Eastern deadline, how will the line move?

Miami could also be sellers, with teams reportedly interested in players like linebacker Jordyn Brooks and defensive tackle Zach Sieler. The Dolphins may not be eager to move on from core pieces of their rebuild, but they may be offered a package of draft picks they cannot refuse.

Tuesday could significantly affect the odds for this weekend’s game, but for now, the Colts are slightly favored.