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Nfl Week 1 Odds & Betting Lines: Super Bowl Rematch To Kick Off Season

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The wait is almost over. The 2026 NFL season kicks off next week with a loaded Week 1 slate featuring marquee matchups on two continents.

The season opens Wednesday, September 9, when the defending champion Seattle Seahawks host a Super Bowl LX rematch against the New England Patriots in a blockbuster opening-night matchup.

Two days later, the NFL heads Down Under as Australia dips its toe into the action, with the San Francisco 49ers and Los Angeles Rams meeting at the Melbourne Cricket Ground on Thursday, Sept. 10 (Friday in Australia).

With Week 1 fast approaching, we're tracking the latest NFL odds, spreads, moneylines, and totals for every game on the opening-week slate.

NFL Week 1 Odds

Matchup	Spread	Win Probability	Over/Under
Patriots vs Seahawks	+3.5 39% -3.5 61%	39% 61%	o44.5 48% u44.5 53%
49ers vs Rams	+3.5 50% -3.5 50%	37% 63%	o47.5 50% u47.5 50%
Bears vs Panthers	-2.5 53% +2.5 48%	59% 41%	o47.5 47% u47.5 53%
Buccaneers vs Bengals	+3.5 50% -3.5 50%	35% 65%	o50.5 52% u50.5 48%
Ravens vs Colts	-3.5 48% +3.5 52%	63% 37%	o50.5 51% u50.5 49%
Bills vs Texans	-1.5 45% +1.5 55%	51% 49%	o44.5 50% u44.5 50%
Saints vs Lions	+6.5 47% -6.5 54%	26% 74%	o50.5 48% u50.5 52%
Jets vs Titans	+2.5 49% -2.5 51%	44% 56%	o38.5 52% u38.5 48%
Browns vs Jaguars	+7.5 48% -7.5 52%	22% 78%	o40.5 47% u40.5 53%
Falcons vs Steelers	+3.5 56% -3.5 44%	39% 61%	o42.5 48% u42.5 52%
Commanders vs Eagles	+4.5 48% -4.5 52%	32% 68%	o45.5 49% u45.5 51%
Packers vs Vikings	+1.5 52% -1.5 48%	49% 51%	o45.5 49% u45.5 51%
Cardinals vs Chargers	+10.5 54% -10.5 46%	19% 81%	o46.5 47% u46.5 53%
Dolphins vs Raiders	+3.5 51% -3.5 49%	34% 64%	o40.5 50% u40.5 50%
Cowboys vs Giants	-2.5 55% +2.5 45%	58% 42%	o48.5 50% u48.5 50%
Broncos vs Chiefs	+2.5 51% -2.5 49%	44% 56%	o43.5 50% u43.5 50%

Percentages courtesy of Kalshi, one of the best prediction market apps.

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Buccaneers vs Bengals odds: Former No. 1 picks collide

In a battle of former No. 1 overall picks and Heisman winners, Baker Mayfield and the Tampa Bay Buccaneers will head to Paycor Stadium to face Joe Burrow and the Cincinnati Bengals as part of Sunday's afternoon schedule.

Mayfield has had the upper hand in this matchup, boasting a 3-1 record in four head-to-head meetings with Burrow. However, Kalshi gives Cincinnati a 65% win probability as the Bengals look to make it four straight wins over Tampa Bay as a franchise.

Ravens vs Colts odds: Indy's Week 1 blues

Before defeating the Miami Dolphins in Week 1 last year, the Indianapolis Colts had gone 2-12-1 in their previous 15 season openers.

Now they'll face a Baltimore Ravens team beginning a new era under head coach Jesse Minter. Lamar Jackson says he's "absolutely" ready for Week 1 after spending the offseason learning a new offense, and Kalshi gives Baltimore a 63% win probability in Indianapolis.

Cardinals vs Chargers odds: Lopsided line

The Los Angeles Chargers enter Week 1 as one of the biggest favorites on the board, with Kalshi giving Justin Herbert and Co. an 81% win probability against the rebuilding Arizona Cardinals.

Herbert offered a glimpse of what the Chargers' new offense could look like in the preseason finale, connecting with Quentin Johnston for a 65-yard touchdown in Mike McDaniel's system. Now they'll look to carry that explosiveness into a favorable Week 1 matchup.

Primetime prowess

The John Harbaugh era in Gotham begins on Sunday Night Football when the New York Giants host the Dallas Cowboys. Jaxson Dart will make his first Week 1 start, while Malik Nabers is trending toward being available after missing time during the preseason.

Meanwhile, the Kansas City Chiefs are set to host the Denver Broncos on Monday, September 14, with all eyes on the potential return of Patrick Mahomes as Kansas City opens the season against its AFC West rival.

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